Analysis of the role of miRNAs in the process of endothelial mesenchymal transition during angiogenesis

Abstract

Endothelial to mesenchymal transition (EndoMT) is a cellular process where endothelial cells gradually remodels their morphology helping the cells to acquire invasive and migratory abilities that is relevant in the number of pathological processes and development. Angiogenesis is the process of formation of new blood vessels from pre-existing ones and VEGF is the major inducer of this process. miRNAs are small non coding RNAs and effective micro regulators of gene expression in number of pathological processes. miRNAs are important regulators of different biological processes and is reported to play vital role in many pathological conditions. The objective of this study is thus to check if VEGF can induce EndoMT and if so, to identify the role of microRNAs under such conditions. newline