Clinicopathological Significance Of Expression Of Pro Angiogenic Vascular Endothelial Growth Factor VEGF In Meningiomas A Retrospective Study

Abstract

A I M A N D O B J E C T I V E S newline6 newlineAIM AND OBJECTIVES newlineAIM newlineand#61623; To determine the clinicopathological profile of meningiomas newlineand correlate the expression of vascular endothelial growth newlinefactor (VEGF) using immunohistochemistry. newlineOBJECTIVES newlineand#61623; To determine the clinicopathological profile of meningioma newlinespecimens received in our institution newlineand#61623; To examine the frequency of peritumoural brain edema newline(PTBE) in various subtypes of meningiomas newlineand#61623; To evaluate VEGF expression using immunohistochemistry in newlinevarious subtypes of meningiomas newlineand#61623; To correlate the grade of VEGF expression with the newlinehistomorphological grade newlineand#61623; To establish the association of VEGF in development of newlineperitumoural edema newlineand#61623; To correlate VEGF positivity with malignant phenotype, such newlineas brain invasion and recurrence. newlineand#61623; To evaluate proliferative potential of various types of newlinemeningiomas using immunohistochemistry with Ki-67 newlineproliferative index. newlineand#61623; To compare the efficacies of VEGF and Ki-67 markers in newlinepredicting aggressive behavior in meningiomas. newline