Study on association of pulmonary diseases in patients with gastro esophageal reflux disease GERD

Abstract

150 subjects of endoscopically proven GERD patients were evaluated for the newlineprevalence and types of Respiratory disability by detailed history, clinical examination, , newlineChest x-ray, Peak Expiratory Flow Rate(PEFR) and Spirometry. newlineThere was a male preponderance of 63% in our study. Majority (69.4%) of patients newlinewere under the age group of 18-30 years and 48% of the subjects were overweight. newlinePredominant Respiratory Symptoms were Breathlessness 78%, Cough 69%, and newlineWheeze 65%. Nocturnal symptoms of GERD were reported in 59%., Predominant GERD newlineSymptoms Epigastric Chest pain 81% followed by Regurgitation 77%, Heart burn 76.67% newlineand Belching 68%. newlineEndoscopic findings revealed 89% of Lax LES, Antral Gastritis was observed in newline87%of the patients, 67% of subjects had Reflux Esophagitis and 35% of patients were newlinediagnosed to have Hiatus Hernia. newlineOut of 67% subjects who had Reflux Esophagitis, 29% had GRADE A reflux newlineesophagitis followed by Grade B and C which was 26% and 15% respectively. newline48% of GERD patients were smokers, out of which 28.67% smokes more than 10 newlinepack years, 19.33% smokes less than 10 pack years. newlineOn correlation of symptoms of Gastro Esophageal Reflux Disease with severity of newlineAsthma and COPD, there exists no significant statistical correlation between any symptoms newlineof GERD and severity of BA and COPD. newlineBronchial Asthma and COPD in GERD were found to be 52.67% and 47.3% newlinerespectively. There was a co-existence of 14.6% of OSA and 6% of ILD in GERD patients newlinewith OAD respectively. newlineAs regards the comparison of severity of endoscopic findings of GERD with severity newlineof Bronchial Asthma, Majority (35.4%) had Grade B Reflux Esophagitis. Moderate Asthma newlinewas seen in all Grades A (65%), Grade B (78.5%) and Grade C (65%) of Reflux Esophagitis newlineand correlation of severity of GERD and BA was shown to be statistically significant (p newlinevalue - lt0.025) newline11.39% of Bronchial Asthma patients had co-existing OSA in our study. Out of this newline66.6% had mild OSA and 46.1% had severe OSA. Out of 6% Patients who had ILD 44.44% newlinewere found to be co-existing