Clinical correlation of outcome of COPD patients with bode index cat score and DLCO

Abstract

The study population showed majority of the COPD patients above 51 years newlineof age with a mean age of 57.13 ± 8.318 showing a male preponderance 63%)and newlinebusinessmen (28%)being at high risk for COPD.70% were smokers and 30% were newlinenon smokers. Out of the 70 smokers 34.28% were current smokers, 41.42% were newlineex smokers, 24.28% were passive smokers where in 23.52% were males and newline76.47% were females. There were no female current and ex smokers. Out of the 30 newlinenon smokers,15% were exposed to biomass fuel exposure with all of them being newlinefemales. The mean BMI was 22.61± 3.643 with majority having a normal newlineBMI(74%).Majority of them had Grade 2 to grade 3 dyspnoea according to MMRC. newlineThe mean FEV1/FEV6 was 0.80± 0.314 and mean FEV6 was 2.06± 0.422. newlineThe mean CAT score was 20.00± 5.507 and majority(50%)had a score between 10 newline 20.About 47.14% of smokers had a CAT score above 20. Patients exposed to newlinebiomass fuel (66,66% ) had a score between 10 - 20 . Majority of the patients (85%) newlinehad a six minute walk distance between 150MTS 349 MTS with a mean of newline258.90± 59.132. About 87% of smokers had a six minute walk distance between newline150 349 MTS. newline66.66% of patients exposed to biomass fuel had a six minute walk distance between newline150 249 MTS.BODE INDEX score was between 3-4 in majority of the newlinepatients(31%) with 4.90± 1.987 being the mean index.28.5% of smokers had a newlineBODE index 7,40% of patients with biomass fuel exposure had a bode INDEX newlinebetween 3-4.with There was a moderate decrease in DLCO%(between 40-60%) in newlinemost of the patients(35%) with a mean of 58.72± 12.912. Majority of the newlinesmokers(37.14%) and patients exposed to biomass fuel(33.33%)showed a mild newlinedecrease in DLCO%(gt 60 - lt 75%).Majority of the patients had mild to moderate newlinePAH. newlineCorrelation between FEV1/FEV6 measured by vitalograph and FEV1/FVC newlinecalculated by spirometry showed a positive correlation with a significance of 0.033 newlineindicating that FEV1/FEV6 can be used as an alternative to FEV1/FVC. FEV1/FEV6 newlinewhen correlated with BODE index, CAT score and PAH showed a negative newlinecorrelation with a significance of 0.000. There was a significant positive correlation newlinebetween FEV1/FEV6 and six minute walk test(6 MIN walk test) with a significance newlineof 0.000.There was a significant negative correlation between FEV1/FEV6 and newlineMMRC grading with a significance of 0.000.There was a significant negative newlinecorrelation between FEV1/FEV6 and passive smoking with a newlinesignificance of 0.000 There was a positive correlation between female newlinepassive smoking BODE index,(significance of 0.005)and CAT score(0.0007).There newlinewas no significant correlation between FEV1/FEV6 and DLCO%. No significant newlinecorrelation was found in between smokers ,biomass fuel exposure and BODE index, newlineCAT score, DLCO%, MMRC grading, six minute walk test(6MIN walk test).There newlinewas no significant correlation between smokers ,biomass fuel exposure with PAH. newlineTherefore the study suggests that FEV1/FEV6 can be used as an alternative newlineto FEV1/FVC. A decrease in Lung function as measured by FEV1/FEV6 was newlineassociated with a significant increase in BODE index, CAT score, PAH, MMRC newlinegrading and a significant decrease in the exercise capacity(six minute walk newlinetest).There was a significant positive association between passive smoking ,BODE newlineindex and CAT score while a significant negative association was observed between newlinepassive smoking and decrease in lung function. newline