Effect of Phospholipid in Combination with Flavonoid On Diabetic and Aphrodisiac Activity

Abstract

Abstract: Phytosome is a complex between natural active ingredient and a phospholipid. Further, phytosomes been applied to many popular herbal extracts or active molecules for augmenting oral dissolution. Therefore, in present investigation, orally administered Baicalein, atype of flavanoids, is poorly absorbed, and shows suboptimal dissolution. The phytosomes encapsulating baicalein (1:1 Mm) were prepared by reverse phase evaporation method followed by lyophilization. Transmission electron microscopy (TEM) analysis revealed that phytosomes were almost spherical in shape with particle size below 100 nm. The Powder ex-ray diffraction (PXRD) and differential scanning calorimetry (DSC) demonstrated that Baicalein loaded phytosomes were amorphous in nature. Amorphization of therapeutic moiety leads to improvement in dissolution. In conclusion, epigallocatechin loaded phytosomes exhibited promising results and warrant further in vitro andin vivo investigations under a set of stringent parameters for transforming in to a clinically viable product. An inadequate mass and progressive dysfunction of and#946;-cell may lead to the impaired insulin secretion. The deterioration of glycemic control over time is primarily caused of both type 1 (T1D) and type 2 diabetes (T2D). Here, we make phytosome of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, had no effect on food intake, body weight gain, circulating lipid profile, and insulin sensitivity in obese mice. Using another rat model of type 2 diabetes induce by streptozotocin injection. We found that Baicalein and Baicalein phytosomes treatment significantly improved hyperglycemia in treated rats, but Baicalein phytosomes have more significant effect than baicalein In the histology study, Baicalein phytosomes 16 significantly reduces pancreatic islet size and and#946;-cell numbers compared to the Streptozotocin induced diabetic rat pancreatic 17 islet cell. The pancreatic islets of Baicalein phytosomes group also show a better physiological shape with