Designing and Synthesis of Quinoline Based Novel Architectures as Anti infective Agents

Abstract

N-heterocyclic compounds represent the important class of organic compounds and they are endowed with broad range of applications in the field of agriculture, pharmaceutical and material sciences. Interestingly, about 90% of the new clinical candidate encompasses heterocyclic ring. Among these privileged scaffolds, quinoline embedded heterocycles are structural component of many natural products and biologically active compounds due to their extensive pharmacological properties. These compounds exhibit a wide range of pharmaceutical potential such as antimalarial, antitubercular, anti-leishmanial, antibacterial, anti-inflammatory, anti-arrhythmic, anti-asthmatic, and anticancer activities. Due to their immense therapeutic significance associated with the quinoline skeleton, these are often used for the design of many synthetic drugs with diverse pharmacological properties; therefore, several methodologies have been established for their synthesis. The convenient approaches to construct the quinoline embedded biologically interesting molecules, the pre-functionalised quinoline containing moieties are extensively explored. In this perspective, 2-chloro-3-formyl quinolines have emerged as a magnificent precursor having multiple sites for diversification towards the construction of bioactive quinoline derivatives with required pattern of substitution. Encouraged by these immense medicinal significance of quinoline moieties, we aimed towards the design and synthesis of quinolines composing with heterocyclic structures. newlineWith regard to our research interests, we have analysed the synthetic utility of 2-chloro-3-carbaldehydes to produce diversely substituted fused heterocyclic structures by using novel synthetic protocols. It is noteworthy to mention that, Vilsmeier-Haack reaction, Sonogashira coupling and Morita-Baylis-Hillman reactions are used to synthesize the quinoline based intermediates. However, and#946;-carboline based substrates synthesized by employing Pictet-Spengler approach followed by oxidation of C-