phytopharmacological studies of myrica nagi against experimentally induced obesity

Abstract

Aim: To validate the efficacy of Myrica nagiagainst experimentally induced obesity in mice. newlineMethods: MEMN was extracted with various solvents like Hexane, Chloroform, Ethyl acetate and Methanol. The extracts were subjected for phytochemical screening to identify different phytoconstituents. Total phenolic, flavonoid and tannin contents were estimated in extracts. Enzymatic activities on and#945; amylase, and#945; glucosidase, lipase was also done. The methanol extract was subjected to HPTLC fingerprinting and method development. Anti-obesity activity of MEMN was studied using HFD, GTG and progesterone models and changes in anthropometric measures, Biochemical parameters, and histo-pathological architecturewere assessed. newlineResults: Phyto-chemical investigations revealed the presence of tannins, amino-acids, flavonoids, saponins and glycosides in various extracts of M.nagi. The methanolic extract of M. nagi (MEMN) showed the highest inhibitory activity against lipase, and#945;-amylase, and and#945;-glucosidase. MEMN administration at various doses significantly reduced the induced weight gain, feed intake, BMI, and Lee index along with various biochemical parameters. The histological changes partly prevented in animals treated with the high dose of extract. newlineDiscussion and Conclusion: Our study indicate that methanol extract of M. nagi aids decrease absorption of cholesterol and triglycerides, thus decreasing serum levels, also study supports hypothesis that decrease in adipose tissue, improved insulin sensitivity, better cardiac as well as hepatic function as a result of presence of phenolic compounds. newline newline