Evaluation of Traditional Indian Medicinal Plants for Therapeutic Implications in Alzheimers Disease

Abstract

Alzheimers Disease is the most general form of dementia characterized by memory decline and loss of cognition. AD affects approximately fifty million people worldwide with an exponential increase of almost half a million fresh cases every year. At present no cure is available for AD due to complex nature of the disease. AD therapeutics mainly involve symptomatic treatment only and is limited to cholinesterase inhibitors such as tacrine and donepezil like drugs used as cognition enhancers. Multiple disease targets are reported that are involved in progression of AD. These are identified as AP peptide aggregation, cholinesterase enzymes, BACEI and MAO-B enzymes. In view of this, the current study focused on strategy to find the novel molecules from selected traditional medicinal plants that can inhibit AD targets such as inhibition of Ap aggregation; inhibition of enzyme responsible for APP mis-cleavage, BACEI; Anti-oxidant potential and anti-cholinesterase potential. newline newline