Dehydrogenative Functionalization of Alcohols Using a Few Well Defined Nickel Catalysts

Abstract

newline The work presented in this thesis entitled Dehydrogenative Functionalization of Alcohols newlineusing a Few Well-Defined Nickel Catalysts was sprouted with an aim to develop sustainable newlinecatalytic methodologies for the construction of various important organic compounds via newlinenickel-catalyzed dehydrogenative functionalization of inexpensive, eco-friendly, and newlineenvironmentally benign alcohols as the primary feedstock. newlineIn this dissertation, a few biologically important and pharmaceutically relevant N-heterocycles newlineand and#945;-alkylated ketones were synthesized via nickel catalyzed alcohol functionalization newlinereactions. Two different classes of nickel catalysts differing in their mode of activation (oneelectron newlineHAT process vs. two-electron hydride transfer pathway) during catalysis were used newlineto study the dehydrogenative functionalization reactions. A comparative study between their newlinecatalytic activities was also investigated. This research is primarily committed to newlineunderstanding the advantages/disadvantages between the two-electron hydride transfer newlineprocess and the one-electron hydrogen atom transfer (HAT) pathway during the newlinedehydrogenative functionalization of alcohols. newlineThe present work was initiated in September 2016 at the Department of Chemistry, Indian newlineInstitute of Engineering Science and Technology, Shibpur, under the supervision of Dr. Nanda newlineDulal Paul. newlineIn keeping with the general practice of reporting scientific observation, due acknowledgments newlinehave been made whenever the work described was based on the findings of other investigators. newlineI must take responsibility for any unintentional oversights and errors, which might have crept newlinein, despite all precautions.