Peptide-Based Inhibitors of Huntingtin Exon I Aggregation

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disorder that becomes more severe with age. There is no specific therapeutic or treatment to date that can cure HD. However, scientists worldwide are continually working to find out effective therapies for HD. Since the identification of the HD gene, nearly 25 years ago, there has been enormous progress in understanding HD pathology's molecular features at the cellular level. These studies have led to the beginning of a systematic process of target selection and validating the potential HD therapeutic candidates.