Phytochemical and Antimicrobial Studies of Certain Aromatic Plants Against Multidrug Resistant Human Pathogens

Abstract

Historically, plants have provided a source of inspiration for novel drug compounds, as plantderived medicines have made large contributions to human health and well-being. Medicinal plants constitute an effective source of both traditional and modern medicines. Plant-based antimicrobials have enormous therapeutic potential as they can serve the purpose without any side effects that are often associated with synthetic antimicrobials. Further continued newlineexploration of plant-derived antimicrobials is needed today. In the present study, methanol and acetone extracts of three medicinal plants were processed for photochemical studies. Further, these potent plant extracts were screened for antimicrobial activity against six standard strains of microorganisms. A substantial difference between MIC from the Plant same extracted by the Soxhlet extraction newlineprocess and Fresh Plant sample extracted during the study was observed for Eucalyptus newlinecitriodorthe a. Whereas, the difference between MIC from Plant samples of both (Coriandrum sativum and Mentha Piperita) extracted by the Soxhlet extraction process and Fresh Plant samples extracted during the study did not show much difference. During RP- HPLC, 11, 8, and 6 fractions were obtained from a plant extract of Coriandrum sativum, Mentha piperita and Eucalyptus citriodora, respectively. Minimum inhibitory concentration (MIC) was determined newlinefor quantifying the antimicrobial activity of bioactive components from coriander leaf extract on the microbes investigated. The bioactive component of plant extract (C6-2) (plantaricin) is having a range of the peak so it contains a bioactive compound that the efficiency of the peak is comparable with the MIC values of C6-2 of the extract. As clear fromqualitative results, Staphylococcus aureus and Pseudomonas aeruginosa have demonstrated the most and the least newlinesensitivity to the extract respectively. There was no toxic effect of the extract of Coriandrum sativum, Mentha piperita and newlineEucalyptus citriodora on human RBCs.