Analysis of breast cancer specific miRNA mRNA TF relationship using genomic signal processing techniques

Abstract

Cancer is a leading cause of death in a developing country like India. It is newlinebasically a disease of genes gain bad . Gene expression controls the way a cell newlinegrows, divides and dies. The identification of genomic regulatory elements is an newlineimportant but unresolved problem in genome annotation. The portion of DNA newlinetranslated to protein is known as coding genes, which carry important information newlinefor protein synthesis. The other portions of DNA which is transcribed to RNA, but newlinedo not get translated to protein are called the noncoding genes. Identification of newlinenoncoding genes target will give a new insight into the field of genomic research. newlineRecently it has been understood that the noncoding RNAs (ncRNAs) play a major newlinerole in a majority of the biological processes. Non coding RNA molecules are newlinemolecules that perform various functions without getting translated into proteins. newlineAs RNAs can interact with other RNAs and DNAs in a sequence-specific manner, newlinethey are especially useful in tasks that require highly specific nucleotide newlinerecognition. Investigation on the roles of miRNA in breast cancer represents a newlinedeveloping and promising research field in the war against cancer. As the newlineemergence of new knowledge and technologies are continuously happening, novel newlineand effective anti-cancer strategies are becoming increasingly possible. Clinical newlinemanagement of human cancers will greatly benefit from the development of micro newlineRNA (miRNA) based diagnostic and therapeutic approaches, and the pharmaceutical newlineindustry is also welcoming a new challenging opportunity in this exciting process. newline