Design and Synthesis of Therapeutically Potential and#946; Carboline Based Molecular Architectures via Exploration of Formyl and#946; Carbolines

Abstract

Natural products are the richest source of novel molecular scaffolds endowed with massive structural and chemical diversity. The advances in natural product discovery have made a significant contribution not only in chemistry but also in the field of biochemistry and medicine. Over the past few decades, they have remained the best sources of drugs and drug leads. It has been estimated that more than one quarter of the drugs which are clinically used are derived from natural products. Inspired by the significance of natural products, this research work is aimed at the design and synthesis of and#946;-carboline containing heterocyclic frameworks and evaluation of their fluorescence properties. and#946;-Carboline belong to a class of indole alkaloids which are associated with a broad range of biological activities. These alkaloids are considered as a privileged scaffolds and it is further evident from the fact that numerous drugs containing the indole structural moiety are clinically used for the treatment of various ailments. newlineIn view of the above discussion, we have explored the synthetic utility of formyl and#946;-carbolines to generate various and#946;-carboline tethered heterocyclic frameworks by employing established or novel synthetic methodologies. It is worthwhile to mention that classically, the Pictet-Spengler approach is generally used for the synthesis of and#946;-carbolines but we have utilized 1(3)-formyl-9H-and#946;-carbolines (an alkaloid) as the precursor during the entire study for the diversity oriented synthesis (DOS) of and#946;-carboline derivatives. For the sake of clarity and convenience in presentation, the work done in the thesis has been divided into the following 5 chapters: newline1. General Introduction and Review of Literature newline2. Transition Metal-free Synthesis of and#946;-Carboline Tethered Molecular Architectures from 1/3-Formyl and#946;-Carbolines and 1-Acetyl and#946;-carbolines via Sulfur Insertion Strategy newline3. Transition Metal-free Synthesis of and#946;-Carboline Tethered Molecular Architectures from 1/3-Formyl and#946;-Carbolines via Multicomponent Approaches newline