Palladium Catalyzed Stereo Controlled Synthesis of 2 Deoxy Aryl C Glycosides

Abstract

C-Glycosides are found in nature and showed various biological activities. Cglycosides newlineare more stable when compared with O-glycosides since they are inert towards newlinethe enzymatic or chemical hydrolysis. Because of the stability, C-glycosides have become newlinethe primary choices for the development of carbohydrate based drugs. Recently, there has newlinebeen tremendous interest towards the development of sugar based drugs, vaccines, newlinecosmetics, diagnostic tools, etc. due to their structural diversity and favorable newlinephysicochemical properties. newlineIn this context, the thesis entitled Palladium-Catalyzed Stereo-Controlled newlineSynthesis of 2-Deoxy Aryl-C-Glycosides will introduce various methods for synthesis of newline2-Deoxy aryl-C-glycosides. Chapter 1 gives a general introduction to different glycosides newlineC-glycosides, S-glycosides, O-glycosides and N-glycosides compounds, mainly about 2- newlinedeoxy aryl-C-glycosides. Chapter 2 will introduce the palladium catalyzed newlinestereocontrolled synthesis of aryl-C-glycosides using glycals and arenediazonium salts at newlineroom temperature. Chapter 3 will describe the palladium-catalyzed one-pot stereospecific newlinesynthesis of 2-deoxy aryl-C-glycosides from glycals and anilines in the presence of tertbutyl newlinenitrite. Chapter 4 will highlight the palladium catalyzed stereo-selective 1,4- newlineconjugate addition of arylboronic acids to enones derived from glycals. Chapter 5 will newlinepresent the palladium-catalyzed regioselective oxidative heck coupling arylboronic acids to newlineglycal enones: a simplest approach for the stereoselective preparation of 2-deoxy and#946;-aryl-cglycosides. newlineFinally, Chapter 6 will summarize and conclude the total thesis work. newline