L amino acid based amphiphilic polymers for drug delivery application

Abstract

L Amino acids are biologically active molecules and play vital role in many biological processes Synthetic polymers based on L amino acids have attracted much attention because of their excellent biocompatibility and diverse functionality which provides them improved hydrophilicity and an opportunity for further modifications with bioactive molecules Development of synthetic strategy for synthesis of amino acid based polymers has great research opportunity in biomedical field The aim of this thesis work is development of a green synthetic route for the synthesis of L amino acid based polyurethanes and poly ester urethanes for drug delivery applications in cancer cells L Lysine was employed to synthesise new class of thermo responsive polyurethane nanocarriers to deliver anticancer drugs by exploiting slightly elevated cancer tissue temperature 42 deg C compared to physiological conditions 37 deg C L Tyrosine and L DOPA resources were suitably modified with masked monomer approach and subjected for melt polymerization to make new classes of enzyme responsive phenol functionalized poly ester urethanes s The aromatic pi stacking secondary interactions between the polymer chains and polyaromatic anticancer drugs were explored for drug stabilization at the nano confinement Further new class of completely bio based polymers were developed using sugar based diols and L amino acids monomers for futuristic completely biodegradable polymers in the biomedical field The dual ester urethane condensation was successfully demonstrated for variety of amino acids including glycine L alanine L valine L leucine L isoleucine and L phenylalanine The occurrence of melt polymerisation and structure of polymers was confirmed by NMR technique The end group analysis by MALDI TOF MS confirmed the stability of both the monomers under melt condition The amino acid sugar hybrid polyester urethane s were showing relatively high glass transition temperature Tg 8805 80 0C compare to their aliphatic diol based polyester urethane s cou