EFFECT OF BENZOa PYRENE ON ANTIOXIDANT DEFENCE SYSTEM OF HIPPOCAMPUS DURING POSTNATAL DEVELOPMENT

Abstract

A polycyclic aromatic hydrocarbon (PAH) like benzo[a]pyrene (B[a]P) is a potent newlineneurotoxicant, which exert its adverse effect by inducing oxidative stress leading to altered newlineneurobehavior, cytomorphometry and receptor expression. Hippocampus is the principal newlinecentre of brain known to play a central role in mood functions and learning memory. To newlineascertain the possible role of B[a]P inducing neurodegenerative phenotype through induction newlineof oxidative stress during early adolescence period, a novel mode of single intracisternal newlineadministration of B[a]P was carried out in five days old rat pups. newline