Novel Approaches to Treat Disorders of Thrombosis And Hemostasis

Abstract

Activated platelets, regardless of the nature of their stimulus, initiate energy-intensive newlineprocesses that sustain thrombus, while adapting to potential adversities of hypoxia and nutrient newlinedeprivation within the densely packed thrombotic milieu. We have recently shown that newlinestimulated platelets switch their energy metabolism to aerobic glycolysis by modulating newlineenzymes at key checkpoints in glucose metabolism, which is mediated by AMP-activated newlineprotein kinase (AMPK) and Src tyrosine kinase. Aerobic glycolysis, in turn, accelerates flux newlinethrough the pentose phosphate pathway and supports platelet activation and function through newlinegeneration of reactive oxygen species by NADPH oxidase. newline