Antihistaminic anti inflammatory and anticholinergic activity of Premna latifolia methanolic leaves extract

Abstract

Atopic dermatitis, allergic rhinitis, and asthma are all serious allergy disorders that newlineaffect millions of people around the world. Immediate or immediate-type newlinehypersensitivity reactions are the traditional names for allergic disorders, and newlineimmunoglobulin E is a key component. In the allergic inflammatory response, mast newlinecell activation mediated by the high affinity IgE receptor is a crucial step. When IgE newlinemolecules and their high affinity receptors are cross-linked in response to allergen newlinestimulation, a complex series of biochemical reactions occurs, including calcium newlineinflux, cytoskeletal reorganisation, and activation of protein tyrosine kinases, newlinephospholipases, protein kinase, and mitogen-activated protein kinases. newline