Study on the outcome of stroke in relation to serum lipid profile

Abstract

Stroke is one of the most common cause of mortality and long term severe newlinedisability. Dyslipidemia is established as a risk factor for cerebrovascular accidents newlinein various studies. Patients with elevated total cholesterol, LDL cholesterol and newlinedecreased HDL cholesterol are at a higher risk of developing stroke. newlineNon HDL cholesterol is total cholesterol minus HDL cholesterol. In a recent newlineanalysis of data combined from 68 studies it is found that non-HDL-C was the best newlinepredictor among all cholesterol measures, both for coronary artery disease events newlineand for strokes. newlineSeveral studies have also established the association between Lipoprotein (a) newlineand stroke. Lipoprotein (a) is an important risk factor for premature stroke among newlineAsian Indians and south Asians especially in those younger than 40 years of age. newlineBoth lipoprotein (a) and non HDL cholesterol were established as newlineindependent risk factors for stroke. Here in this study we assess the severity of newlinestroke in relation with lipoprotein (a) and non HDL cholesterol levels.Elevated non HDL cholesterol and lipoprotein (a) were established as newlinepredictors of severe stroke, with lipoprotein (a) being a better predictor. We also newlinefound that increase in both non HDL and LP (a) is a better predictor of severe stroke newlinethan isolated increase in LP (a). newlineAs reliable early prediction of severe stroke helps in improving the patient s newlinefunctional outcome and long term disability, this area requires further research newline