Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/437664
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dc.coverage.spatialNovel Molecules Targeted For Neuropathic Pain
dc.date.accessioned2023-01-06T05:56:46Z-
dc.date.available2023-01-06T05:56:46Z-
dc.identifier.urihttp://hdl.handle.net/10603/437664-
dc.description.abstractPain is commonly known as a disruptive sentiment which is results of forceful and damaging stimuli. It is generally classified as the chronic and acute pain depending upon the magnitude in between them. Neuropathic pains are regularly associated with the chronic form which is result of the injury in the somatosensory nerves. 7-10% of the general population is found to be affected by neuropathic pain and it is normally associated with the sever clinical condition as more than 60 % of cases are associated with diabetic, cancer and other several injuries. The treatment regime of this neuropathic pain include various agents like antidepressant, anticonvulsants and opioids although this treatment regime can be able to reduce the pain by 30-50% but repeatedly gives neurological adverse effects like sedation and addiction. Sodium Channel 1.7 (Nav 1.7) is one of the promising biological targets for the development of the molecules against neuropathic pain. Via the reaction of indole 3-carboxyaldehyde fourty different heterocyclic derivatives were prepared by using two scheme. Novelty molecules confirmed by Scifinder database. Molecules that are synthesized are characterized via by IR, Mass, C13 and H1 NMR spectral analysis. All the synthesized derivatives were found to be interacting with Nav 1.7 which indicated further biological optimization of these compounds may lead to potent Nav 1.7inhibitors. Neuropathic pain activity of synthesised compound carried out by streptozocine (STZ) induced diabetic pain model. These synthesized compounds were screened for various behavioural study such as Eddy s Hot plate method, Tail flick, motor co-ordination and other methods. After the behavioural study the sciatic nerve of the rat dissected and biochemical estimation and histopathology study is carried out. Result indicate the SS10 and SS21 and SS2(9) restored the GSH levels in Diabetic animals. Catalase levels in the sciatic nerves of DN rats were significantly less compared to Control animals. SS10 and SS2 (15) treatment restored the C
dc.format.extent249p
dc.languageEnglish
dc.relation145b
dc.rightsuniversity
dc.titleDesign and Development of Some Novel Molecules Targeted For Neuropathic Pain
dc.title.alternative
dc.creator.researcherSonvane Sameep Madhukarrao
dc.subject.keywordClinical Pre Clinical and Health
dc.subject.keywordPharmacology and Pharmacy
dc.subject.keywordPharmacology and Toxicology
dc.description.note
dc.contributor.guideBhusnure Omprakash G.
dc.publisher.placeNanded
dc.publisher.universitySwami Ramanand Teerth Marathwada University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered2017
dc.date.completed2022
dc.date.awarded2022
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File584.24 kBAdobe PDFView/Open
02_certificate.pdf361.62 kBAdobe PDFView/Open
03_abstract.pdf285.5 kBAdobe PDFView/Open
04_decleration.pdf357.45 kBAdobe PDFView/Open
05_acknowledgment.pdf289.9 kBAdobe PDFView/Open
06_contents.pdf155.05 kBAdobe PDFView/Open
07_list of _tables.pdf126.05 kBAdobe PDFView/Open
08_list_of_figures.pdf78.85 kBAdobe PDFView/Open
09_abbrevations.pdf183.08 kBAdobe PDFView/Open
10_chapter 1.pdf998.42 kBAdobe PDFView/Open
11_chapter 2.pdf1.34 MBAdobe PDFView/Open
12_chapter 3.pdf1.41 MBAdobe PDFView/Open
13_chapter 4.pdf13 MBAdobe PDFView/Open
14_conclusion.pdf293.56 kBAdobe PDFView/Open
15_summary.pdf319.46 kBAdobe PDFView/Open
16_bibilography.pdf425.29 kBAdobe PDFView/Open
80_recommendation.pdf654.25 kBAdobe PDFView/Open


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