1. Shodhganga@INFLIBNET
  2. Indian Institute of Science Education and Research (IISER) Pune
  3. Department of Chemistry
Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/437558
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dc.date.accessioned2023-01-06T04:49:44Z-
dc.date.available2023-01-06T04:49:44Z-
dc.identifier.urihttp://hdl.handle.net/10603/437558-
dc.description.abstractThe thesis entitled 8220 Structural control of Peptide Nucleic Acid PNA rotamers and their fluorescence properties aza PNA gemdimethyl G PNA and C 945 S bm PNA monomers and oligomers 8221 describes studies done on the synthesis characterisation and rotamer study of novel aza PNA monomers 945 946 gemdimethyl guanine PNA C 945 S acetamido bm PNA monomers and oligomers The effect of intramolecular H bonding in C 945 NH aza PNA and gem dimethyl substitution induced conformational constraint on rotamer selectivity and the fluorescence properties are explored in this work The thesis is presented in five chapters newline newline
dc.format.extentNA
dc.languageEnglish
dc.relationNA
dc.rightsself
dc.titleStructural control of peptide nucleic acid rotamers aza pna and optical properties of gemdimethyl pna bimodal pna monomers and oligomers
dc.title.alternativeNa
dc.creator.researcherSHIRAJ, ABDUL
dc.subject.keywordChemistry
dc.subject.keywordChemistry Applied
dc.subject.keywordPhysical Sciences
dc.description.noteThis chapter gives an overview of DNA/RNA duplex, triplex and tetraplex structure, chemically modified DNA and Peptide nucleic acid. Synthetically modified oligonucleotide (ODNs) of DNA and RNA are capable of forming Watson-Crick hydrogen bonded duplex between the two complementary strands as natural DNA. Polypyrimidine sequences of DNA/RNA oligomers are capable of forming triplexes by combination of Watson-crick and Hoogsteen hydrogen bonding among the three composed strands. The specificity in complementary base pairing to forming stable duplexes and triplexes make synthetic DNA an ideal candidate to suppress undesirable genes and is the basis of new medicinal chemistry concept of antigene and antisense therapy.
dc.contributor.guideGANESH, KRISHNA N.
dc.publisher.placePune
dc.publisher.universityIndian Institute of Science Education and Research (IISER) Pune
dc.publisher.institutionDepartment of Chemistry
dc.date.registered2016
dc.date.completed2022
dc.date.awarded2022
dc.format.dimensionsNA
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Chemistry

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