Understanding the Immunomodulatary Machanism In Pre Term Birth

Abstract

Pre-term birth may be a consequence of altered immune-endocrine crosstalk newlineduring third trimester resulting in early breakdown of maternal fetal tolerance and newlineexpulsion of fetus. An efficient and sustainable establishment of maternal fetal newlinetolerance is required for a healthy successful pregnancy till term. Any untimely abrupt newlinebreakdown in this tolerance might be responsible for premature activation of labor newlineresulting in Pre-term birth. Present thesis work aims to have a better understanding of newlineimmunological alterations assisted by several hormonal and inflammatory factors in newlineregulating maternal fetal tolerance and also to gain insight into factors contributing newlinetowards impaired or compromised immunity of pre-term babies. Through this study, newlinewe intend to investigate role of immunosuppressive cells like Myeloid derived newlinesuppressor cells and T regulatory cells in the maintenance of maternal tolerance and in newlineneonatal immunity. This aspect is very less explored and needs deeper insight and newlinefurther exploration. We have also tried to unravel the involvement of alarmin proteins newlinein regulating non-infectious origin of inflammation. Apart from immunological and newlineinflammatory factors, steroidal hormonal factors also play instrumental role and their newlinesynergistic balanced interplay is very much desired for the maintenance of pregnancy newline