Domino Process For Non Annulated Annulated Pyrroles Application Towards The Total Synthesis Of Some Bioactive Marine Pyrrole Alkaloids and Lamellarin Inspired Molecular Scaffolds

Abstract

The present thesis entitled Domino Process for Non-Annulated/ Annulated Pyrroles: newlineApplication Towards the Total Synthesis of Some Bioactive Marine Pyrrole newlineAlkaloids and Lamellarin Inspired Molecular Scaffolds describes the development of newlinea synthetic methodology to access functionalized pyrroles in a single pot operation. Then, newlinethe application of the methodology for the formal synthesis of ningalin B has been newlinedemonstrated. Later, the total synthesis of several natural and unnatural lamellarins has newlinebeen accomplished in 4-6 linear steps through the application of the methodology. newlineFurther, a domino process for accessing diverse chromenodihydropyrrolizne (CDPs) and newlinechromenotetrahyroindolizine (CTIs) in good to excellent yield as the simplified version newlineof isolamellarins has been demonstrated.