Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/436137
Title: | Design Synthesis and Cytotoxicity Evaluation of Combretastatin Based Heterocyclic Compounds and Development of New Synthetic Methodologies for Bioactive Molecules |
Researcher: | KM Darshana Bora |
Guide(s): | Nagula Shankaraiah |
Keywords: | Chemistry Chemistry Medicinal Physical Sciences |
University: | National Institute of Pharmaceutical Education and Research, Hyderabad |
Completed Date: | 2022 |
Abstract: | The work carried out in my research tenure has been compiled in the form of a thesis entitled Design, Synthesis and Cytotoxicity Evaluation of Combretastatin Based Heterocyclic Compounds and Development of New Synthetic Methodologies for Bioactive Molecules . The main aim of this work is to demonstrate design and synthesis of novel combretastatin based heterocycles conjugates and evaluation of their cytotoxicity potential against selected cancer cell lines along with tubulin inhibition affinity. Apart from this, it also deals with the development of efficient C-H activation methods for the functionalisation of bioactive and#946;-carbolines and isoquinolines. newline |
Pagination: | |
URI: | http://hdl.handle.net/10603/436137 |
Appears in Departments: | Medicinal Chemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01. final thesis - title.pdf | Attached File | 163.32 kB | Adobe PDF | View/Open |
02. general pages.pdf | 4.01 MB | Adobe PDF | View/Open | |
05. final thesis - statement and outline.pdf | 229.87 kB | Adobe PDF | View/Open | |
06. final thesis - contents.pdf | 283.02 kB | Adobe PDF | View/Open | |
08. final thesis - chapter i.pdf | 2.84 MB | Adobe PDF | View/Open | |
09. final thesis - chapter ii.pdf | 9.54 MB | Adobe PDF | View/Open | |
10. final thesis - chapter iii.pdf | 7.55 MB | Adobe PDF | View/Open | |
11. final thesis - chapter iv.pdf | 7.85 MB | Adobe PDF | View/Open | |
12. final thesis - research publications.pdf | 4.77 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 48.08 kB | Adobe PDF | View/Open |
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