Antimicrobial effectiveness of magnesium oxide nanoparticles based intracanal medicament in patients with apical periodontitis a randomized clinical trial

Abstract

The purpose of this study was to evaluate the effect of two intracanal newlinemedicaments against common microorganisms in the infected root newlinecanals. newlineMaterials and Methods newlineIn a prospective randomized clinical trial, 40 patients were selected newlinewith age between 18 to 55 years according to inclusion and exclusion newlinecriteria and preoperative diagnosis, and root canal samples were newlinecollected. Based on block randomisation patients were divided into newlineGroup 1 :Calcium Hydroxide and Group 2 : nano MgO. Routine root newlinecanal preparation was done in both the groups following the standard newlineprotocol until 6% 25 Protaper Gold rotary files with intermittent newlineirrigation with 3% NaOCl. A second sample from the cleaned and newlineshaped root canal was collected. Intracanal medicament was placed newlinebased on the assigned group using lentulospirals and the patient was newlinerecalled after seven days and a third sample from the root canals was newlineobtained and obturation was completed if the patient was newlineasymptomatic. The microbial load ( Porphyromonas endodontalis andPrevotella intermedia) in the root canal samples before and after the newlinetreatment was evaluated by RT-PCR/qPCR and analysed statistically. newlineResults newlineBoth the groups showed decrease in the microbial count against tested newlinemicrobes before initiation of the treatment and after the medicament newlinewas placed in root canals for 7 days. newlineConclusion newlineMagnesium oxide Nanoparticles can be used as an alternative newlineintracanal medicament in reducing the microbial load within the root newlinecanals. However, more clinical trials need to be carried out to arrive at a newlinedefinitive conclusion. newline