Comparative Evaluation Of Pregabalin Dexmedetomidine And Diclofenac Sodium In The Reduction Of Postoperative Pain Following Third Molar Surgery A Randomized Controlled Trial

Abstract

Aim newlineTo evaluate and compare the efficacy of pregabalin and dexmedetomidine against newlinethe control diclofenac in impacted mandibular molars using a randomized newlinecontrolled trial. newlineMaterials And Methods newlineThe present study is a randomized clinical trial conducted on 90 patients newlinebetween the age group of approximately 15-60 years, who had visited the newlinePage 16 of 144 newlinehospital for removal of impacted wisdom teeth. The study participants were all newlinehealthy individuals with no systemic comorbidities. Each participant randomly newlineassigned to one of the three groups, where one group was the control group newlinewhich received diclofenac sodium, while the other two groups were the newlineintervention group which received pregabalin 150mg preoperatively and newlineDexmedetomidine 1ug intraoperatively during the removal of impacted third newlinemolar. The postoperative assessment was carried out in both the groups during newlinepostoperative day 1, 3 and 7 respectively, and significant differences were noted newlinebetween both the groups. newlineResults newlineStatistical analysis of the data indicated the mean pain score during the newlinePreoperative, intraoperative and postoperative period and was significantly newlinedecreased in the Pregabalin group (p=0.01). It was observed that the study group newlineconsumed less analgesic within 24 hours as compared to the control group newlinewhich was statistically significant (P = 0.001). newlineConclusion newlineThe results of our study suggest that preemptive analgesia with pregabalin for newlinesurgical extraction of impacted teeth is effective in reducing postoperative pain. newlineKeywords: Mandibular third molar surgery, Diclofenac Sodium, Pregabalin, newlineDexmedetomidine, randomized controlled trial newline