Role of intrinsic factor cobalamine receptor in Type 2 Diabetes Mellitus

Abstract

Abstract newlineThere are no studies in India that have examined the association of antidiabetic drugs and newlinerisk of decreased B12 levels. Although several studies investigated several genetic determinants newlineof vitamin B12 and their outcomes, studies investigating the relationship of polymorphisms in the newlinevitamin B12 pathway and usage of antidiabetic drugs are limited. The increasing prevalence of newlinediabetes makes it imperative that research should focus on its prevention as well as its treatment. newlineAn improved understanding of the mechanisms linking inflammation to diabetes and related newlinecomplications has stimulated interest in targeting inflammatory pathways as part of the strategy to newlineprevent or control diabetes and its complications. Since metformin is one of the important drugs newlinefor T2DM control, which is combined with other drugs, there is a need to study the involvement. newlineResults from the present study conclude that, the study has led to an important proof against the newlineantidiabetic drugs commonly advised to Type 2 Diabetes Mellitus patients for controlling their blood newlineglucose levels, but instead they are facing the inevitable consequence of being VitB12 deficient and its newlineassociated manifestations. As diabetes itself is a chronic inflammatory disease and diabetics on metformin newlinehave decreased serum B12 as a major side effect. Which itself is a potent stimulator for inflammation newlinewhich leads to microvascular and macrovascular complications like retinopathy, nephropathy, newlinemicrovascular neuropathy, ischemic heart disease, peripheral vascular disease, and cerebrovascular newlinedisease due to decreased scavenging of reactive oxygen species, by increasing homocysteine induced newlineoxidative stress.The present study also indicates the association of gene polymorphisms with increased newlinechances of deficiency of vitamin B12 in both the drug groups. newline