Synthesis of poly nuclear hetero aryl substituted novel terpyridine scaffold and their metal complexes Study on their interaction with ct DNA

Abstract

The photoluminescence molecules have very unique importance in the advancement of science and technology. Here, we studied the poly-nuclear and hetero-aryl substituted novel terpyridine scaffolds.These designed moieties were synthesized by multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of NH4OHand KOH. We have developed the unique protocol to synthesis highly substituted pyridine scaffolds that are not easily accessed by conventional methods. The structures of all newly prepared terpyridine molecules have been well established by preforming various spectral analysessuch as IR, NMR, DEPT, HRMS and single crystal XRD studies for selected molecules. Metal complexes of the terpyridine derivative obtained from 2- acetylpyridine were synthesized by reaction with various transition metals and lanthanides. Structures of all the prepared metal complexes were characterized by IR, MASS and single-crystal X-ray analysis for selected molecules. UV-visible and florescence spectra were recorded for all the synthesized compounds.The prepared scaffolds as such and their metal complexes may provide an efficient candidate for photo-luminescent chemistry.To check the possibility of medical application of prepared molecules, all the compounds were studied for their ct-DNA binding studies by UV absorption and emission spectrometry. The obtained results shown that all these molecules have good binding affinity with ct-DNA. newline