In vitro analysis of centrosema pubescens in induction of differentiation cell cycle inhibition and inflammation mediated apoptosis and in vivo validation of cell cycle regulation

Abstract

Infectious diseases and cancer are potentially the largest threat to newlinehuman race with cancer being the second largest fatal disease in the world newlineKey aspects of cancer biology are cell division and apoptosis and are essential newlinetargets of new anticancer therapies Cyclin Dependent Kinases CDK 1 2 4 newlineand 6 play essential role in intracellular control of cell cycle which form newlinecomplexes with specific regulatory proteins called cyclins A B D and E newlineActivation of cyclinCDK is counterbalanced by CKI P16 and P27 that newlineserves as negative regulator of the cell cycle stopping the cell from advancing newlineto the next phase of the cell cycle newline newline