Metal catalyzed oxidative transformations of carbonyl compounds domino reactions rearrangements and continuous flow applications

Abstract

The metal catalyzed reactions have pivotal importance in chemical synthesis which can be utilized to construct challenging organic scaffold of biological importance with improved sustainability and atom economy In particular the oxidation reactions are profoundly important in chemical biological synthesis and it provides a breakthrough for the synthesis of building blocks precursors towards natural unnatural targets Accordingly the metal catalyzed oxidative C H functionalization offers a direct route to construct the C C C O and C N bond formation and gives access to novel bioactive compounds commercial drugs natural products household products petrochemicals etc The present investigation of this thesis describes C C bond formation by 945 alkylation of unactivated amides C O bond formation via sp3 C H peroxidation in batch continuous flow hydroxylation of carbonyl compounds and novel rearrangement of peroxides using Lewis or Br 248 nsted acid to afford the biologically important scaffolds This thesis describes research findings in the development of 8220 Metal Catalyzed Oxidative Transformations of Carbonyl Compounds Domino Reactions Rearrangements and Continuous Flow Applications 8221 and which comprises of four chapters Chapter 1 Introduction to Oxidative C H FunctionalizationAt the outset the brief introduction of metal catalysis is described concerning the field of chemistry Later the fundamental of oxidation reactions along with an overview of C H functionalization is discussed Then the aim and rationale of the thesis are described Chapter 2 Ruthenium Catalyzed Direct 945 Alkylation of Amides Using Alcohols and C H Hydroxylation of Carbonyl Compounds In this chapter we present a ruthenium catalyzed direct 945 alkylation of unactivated amides and 2 oxindoles using alcohol as an alkylating agent and transition metal free C H hydroxylation of carbonyl compounds Chapter 2 is subdivided into two sections Section A describes a highly efficient protocol for ruthenium pince newline newline