Ruthenium ii and cobalt iii catalyzed cyclization and alkenylation of substituted aromatics with 960 components

Abstract

The thesis entitled 8220 Ruthenium II and Cobalt III Catalyzed Cyclization and Alkenylation of Substituted Aromatics with 960 Components 8221 comprises of four chapters The transition metal catalyzed chelation assisted C 8211 H functionalization of substituted aromatics with electrophiles or nucleophiles is an efficient method to construct chemical bonds in highly atom and step economical manner Various transition metal complexes of palladium rhodium ruthenium and iridium are widely employed as catalysts for this type of transformations Among them due to the unique reactivity and selectivity a less expensive ruthenium arene complex has gained much attention for this type of reactions In addition the reactions catalyzed by ruthenium arene complexes can be performed under air atmosphere and water can be employed as solvent Meanwhile the development of new C 8211 H bond transformation reactions by using more abundant biologically tolerated and sustainable first row transition metal catalysts is also highly important Recently the air stable and inexpensive cobalt complexes are recognized as one of the efficient catalysts for the C 8211 H functionalization reaction In this thesis we aim to develop methods for synthesizing heterocylic moieties using Ru II and Co III catalysts with a combination of suitable directing groups and C 8211 C 960 components Chapter 1 of this thesis discusses the history and classification of C 8211 H activation reactions A brief introduction of chelation assisted C 8211 H bond activation via oxidative addition pathway as well as deprotonation pathway was also discussed with appropriate examples In particular this part discusses about the types and the reaction mechanisms of ruthenium and cobalt catalyzed C 8211 H bond activation reactions Chapter 2 of this thesis describes an efficient method for the Ru catalyzed oxidative cyclization reaction to synthesize structurally diverse isoindolines and pyrroloquinolinones It contains two sub divisions as follows Section 2 newline newline