Studies on roles of Heat shock protiens in initiation and progression of malignant epithelial tumours in Drosophila melanogaster

Abstract

Tumour growth involves changes at various levels ranging from genomic to metabolism for newlinesurvival and propagation. Besides many key oncogenic signalling pathways, metabolic newlinereprogramming also plays a key role during tumourigenesis. Altered metabolism and newlineunfavourable tumour microenvironment, such as low oxygen availability and nutrient newlinedeprivation, exposes the oncogenically targeted cells to intense cellular stress. newline