Protein Folding Function and Aggregation Role of Co solvents and Topological Frustration

Abstract

Proteins are biological macromolecules formed by sequentially joining natural amino acids through peptide bonds. The sequence of amino acids in a protein chain determines its three dimensional structure under physiological conditions. Proteins performdiverse functions such as transporting molecules, transmitting signals between cells, catalyzing metabolic reactions etc. In this thesis I have studied problems related to protein folding, function and aggregation using molecular dynamics simulations and protein models at atomistic and coarse-grained resolution newline