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http://hdl.handle.net/10603/430007
Title: | Construction of Carbon Heteroatom and Heteroatom Heteroatom bonds using Iodine and Zinc catalysts |
Researcher: | Panigrahi, Ahwan |
Guide(s): | Prabhu, K R |
Keywords: | Chemistry Chemistry Organic Physical Sciences |
University: | Indian Institute of Science Bangalore |
Completed Date: | 2021 |
Abstract: | The thesis entitled Construction of Carbon-Heteroatom and Heteroatom-Heteroatom bonds using Iodine and Zinc catalysts has been divided into five chapters. Chapter 1 describes a general introduction to iodine, hyper-valent iodine, and zinc chemistry. Chapters 2, 3, 4 are in Section A. Chapters 2 and 3 describe the role of iodine for C-N and C-S bond formation. Chapter 4 describes the utility of hyper-valent iodine for N-S bond formation. Last chapter 5 is covered under Section B, where zinc catalyst has been used for C-N bond formation. Section A, chapter 2 describes the role of iodine in the C-H functionalization of cyclopentenedione with benzamidine hydrochloride, which leads to fused imidazole derivatives in the presence of iodine/TBHP combination in a short period of time. To support the reaction mechanism, mass spectrometric analysis has been carried out. Section A, chapter 3 covers a multicomponent strategy for C-N and C-S bond formation using thiols, benzaldehydes and trimethoxybenzene using a catalytic amount of iodine. Section A, chapter 4 deals with trifluoromethylsulfonylation of pyrazolone using hypervalent iodine PIFA, which leads to N-triflination instead of C-4 functionalization of pyrazolone. The reaction completes in 5 minutes, leading to a new N-S bond. Section B, chapter 5, represents zinc-mediated C-N bond formation using cinnamyl alcohol and 2-amino pyridines. In this method, ZnBr2 acts as a Lewis acid. The method was found to be compatible with primary alcohol, secondary alcohol as well as homoallyl alcohol... newline |
Pagination: | 145 p. |
URI: | http://hdl.handle.net/10603/430007 |
Appears in Departments: | Organic Chemistry |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 185.06 kB | Adobe PDF | View/Open |
02_prelim pages.pdf | 877.17 kB | Adobe PDF | View/Open | |
03_table of contents.pdf | 33.54 kB | Adobe PDF | View/Open | |
04_abstract.pdf | 73.84 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 1.04 MB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 2.2 MB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 1.9 MB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 2.07 MB | Adobe PDF | View/Open | |
09_annexure.pdf | 141.7 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 2.01 MB | Adobe PDF | View/Open |
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