Effect of Ketogenic Diet Intermittent Fasting and High Carbohydrate Diet on Chronic Inflammation in Male Wistar Rats

Abstract

Background newlineIt has been long recognized that diet is crucial in causation and management of newlinechronic Non Communicable Diseases (NCDs). Chronic inflammation of mild to newlinemoderate intensity contributes to pathogenesis of several NCDs. Literature reveals newlinethat a diet rich in carbohydrate is a crucial risk factor in causation of NCDs. Hence a newlinerational approach to diminish the risk of developing NCDs would be to reduce newlinecarbohydrate consumption by ketogenic diet (KD) or intermittent fasting (IF). Hence, newlinethe current study was undertaken. newlineObjectives: newlineTo determine the effects of ketogenic diet, intermittent fasting, high newlinecarbohydrate diet and a combination of intermittent fasting with ketogenic diet on newlinechronic inflammation (induced by Complete Freund s adjuvant) - (CFA) and newlineoxidative stress parameters in male Wistar rats. newline