Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/429581
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DC Field | Value | Language |
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dc.coverage.spatial | ||
dc.date.accessioned | 2022-12-21T11:25:04Z | - |
dc.date.available | 2022-12-21T11:25:04Z | - |
dc.identifier.uri | http://hdl.handle.net/10603/429581 | - |
dc.description.abstract | Cancer is responsible for millions of death every year. The drugs used to treat cancer bear severe side-effects. Hence, there is always a need for effective and safer molecules against it. It can be achieved either by screening the NCE or repurposing the existing one. The bioisosteric replacement on a synthetically versatile scaffold often gives the molecule with desired biological properties. In-silico analysis of existing drugs is also in use to find new anticancer moiety. Cell line based study, heterocyclic synthesis and CADD play vital role inthe process. newlineObjectives: newlineObjectives of the work is to design, synthesize and screen 2,6-substituted-imidazo[2,1-b] [1,3,4]thiadiazoles as levamisole derivativewith desired cytotoxic property and convert them to a potential lead against cancer newline | |
dc.format.extent | ||
dc.language | English | |
dc.relation | ||
dc.rights | university | |
dc.title | Synthesis Of Levamisole Derivatives For Anti Cancer Activity | |
dc.title.alternative | ||
dc.creator.researcher | Chudamani B | |
dc.subject.keyword | 2-Aralkyl-6-aryl-imidazo[2,1-b][1,3,4]thiadiazole;Cytotoxicity;Apoptosis; Caspase-3; DNA fragmentation;Levamisole;Melplhalan | |
dc.subject.keyword | Clinical Pre Clinical and Health | |
dc.subject.keyword | Pharmacology and Toxicology | |
dc.description.note | ||
dc.contributor.guide | Subhas S.Karki | |
dc.publisher.place | Belgaum | |
dc.publisher.university | KLE University | |
dc.publisher.institution | Faculty of Pharmacy | |
dc.date.registered | ||
dc.date.completed | 2022 | |
dc.date.awarded | 2022 | |
dc.format.dimensions | ||
dc.format.accompanyingmaterial | None | |
dc.source.university | University | |
dc.type.degree | Ph.D. | |
Appears in Departments: | Faculty of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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80_recommendation.pdf | Attached File | 274.92 kB | Adobe PDF | View/Open |
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