Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/429581
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dc.coverage.spatial
dc.date.accessioned2022-12-21T11:25:04Z-
dc.date.available2022-12-21T11:25:04Z-
dc.identifier.urihttp://hdl.handle.net/10603/429581-
dc.description.abstractCancer is responsible for millions of death every year. The drugs used to treat cancer bear severe side-effects. Hence, there is always a need for effective and safer molecules against it. It can be achieved either by screening the NCE or repurposing the existing one. The bioisosteric replacement on a synthetically versatile scaffold often gives the molecule with desired biological properties. In-silico analysis of existing drugs is also in use to find new anticancer moiety. Cell line based study, heterocyclic synthesis and CADD play vital role inthe process. newlineObjectives: newlineObjectives of the work is to design, synthesize and screen 2,6-substituted-imidazo[2,1-b] [1,3,4]thiadiazoles as levamisole derivativewith desired cytotoxic property and convert them to a potential lead against cancer newline
dc.format.extent
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleSynthesis Of Levamisole Derivatives For Anti Cancer Activity
dc.title.alternative
dc.creator.researcherChudamani B
dc.subject.keyword2-Aralkyl-6-aryl-imidazo[2,1-b][1,3,4]thiadiazole;Cytotoxicity;Apoptosis; Caspase-3; DNA fragmentation;Levamisole;Melplhalan
dc.subject.keywordClinical Pre Clinical and Health
dc.subject.keywordPharmacology and Toxicology
dc.description.note
dc.contributor.guideSubhas S.Karki
dc.publisher.placeBelgaum
dc.publisher.universityKLE University
dc.publisher.institutionFaculty of Pharmacy
dc.date.registered
dc.date.completed2022
dc.date.awarded2022
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Faculty of Pharmacy

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