evaluation of pharmacokinetic profile of some nano sized drugs with piperine and some of its synthetic derivatives as a potential bioenhancer

Abstract

Natural products have contributed nearly half of all the small molecules approved as newlinedrugs in this decade. It has been suggested that the current drug discovery approach of finding newline new chemical entities if shifted to combining existing agents , may be helpful. Further, newlinehigher doses, poor absorption, low bioavailability, and poor patient compliance are the major newlinedrawbacks of drugs. Black pepper consists of approximately 5-9 % piperine as an active newlinechemical constituent. Along with the bio-enhancing effect, piperine is well-reported in Indian newlinemedicine for the treatment of diseases such as rheumatoid arthritis, cancer, asthma, newlineinflammation, anxiety, depression, and infectious diseases. Piperine significantly enhances the newlinebioavailability of different drugs such as rifampicin, simvastatin, ibuprofen, and omeprazole. newlineIn the current review, isolation, and extraction, total synthesis, pharmacological activities of newlinepiperine and its derivatives and bio-enhancing properties are discussed. Piperine may be used newlinealong with poor ADMET drugs to enhance the bioavailability, minimize the dose, and possess newlinesynergistic effects in the treatment of various disease states. Increasing preclinical and clinical newlinestudies on the improved pharmacokinetic profile of the drug with piperine alone or with the newlinediet contains piperine as a dietary supplement suggest that the interaction of piperine with the newlinedrug results in the altered ADME pattern (pharmacokinetics) and ultimately leads to better newlinesystemic exposure and tissue distribution of the drug in the body. newline