Delineation of Indian Dill Chemical components and study of selected components for their commercial and therapeutic potentials

Abstract

Anethum sowa L. is an aromatic plant with pharmacological potential. The chemical composition and the therapeutic potential of Anethum sowa L. herb oil grown in South Karnataka is very few; moreover, its essential oil and extract together is not being studied and compared for its effects on colon cancer cell lines HCT -116 and anti collagenase study. The current investigation was intended to sight see the incidence of components present in the herb oil examined by Gas Chromatography-mass spectrometry, antioxidant, antimicrobial, anticancer and anticollagenase potential was investigated and further the insilco docking studies to unleash the potential drug like molecules in the therapeutic plant was studied. 5-Oxo-4,5,6,7-tetrahydro-1Hpyrrolo[2,3-c]pyridine-3-propionic acid methyl ester, (17.41%),beta-Amyrin(8.20),ritodrine(6.49), 1-Naphthalenol,decahydro-1,4adimethyl7(methylethylidene)-,[1R-(1.alpha.4a.beta,8a.alpha)](2.39%),meta-Cymene(1.95%),trans-z-alpha-Bisabolene epoxide (1.80), and Viridiflorol(0.77%) were the new compounds isolated from this therapeutic plant, and Anethum sowa L. newlineherb ethanolic extract contained many potential phytochemicals. The total phenol and flavonoid of the herb extract were 0.136 mg/mL and 0.108 mg/mL respectively. Anethum sowa L. herb extract ABTS antioxidant assay showed excellent activity with an IC50 of 540 L which was in power with gallic acid which showed an IC50 of 393 Anethum sowa L. herb exhibited potent antimicrobial activity against all the three microorganisms E coli strain (MTCC 433), Klebsiella pneumoniae strain (MTCC 3384) Streptococcus mutans strain (MTCC 497) with a minimum inhibitory concentration of 20% herb oil. Cytotoxicity of Anethum sowa L. herb essential oil and ethanolic extract against Colon cancer cell lines - HCT -116, showed that herb oil and herb et hanolic extract repressed the cell growth of the cell. newline