Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/426196
Title: | Identification and Biochemical Characterization of Novel Inhibitors of Nonhomologous End Joining Implications in DNA Double Strand Break Repair and Cancer Therapy |
Researcher: | Ray, Ujjayinee |
Guide(s): | Raghavan, Sathees C |
Keywords: | Biochemical Research Methods Biology and Biochemistry Life Sciences |
University: | Indian Institute of Science Bangalore |
Completed Date: | 2020 |
Abstract: | To summarize, in the present study, we have synthesized and characterized three novel NHEJ inhibitors targeting DNA Ligase IV, with several fold better efficacy compared to SCR7 and thus potential to be developed as cancer therapeutic agents. While SCR130 showed up to 22-fold better efficacy, compounds A and B exhibited gt100 fold better cytotoxicity in cancer cell lines. First level preclinical studies reveal that novel inhibitors, A and B are interesting molecules and could be used in clinical trials for targeted therapy, particularly by a combinatorial mode. Considering that there is no drug currently used in clinic that target DNA double-strand break repair, these NHEJ inhibitors could be developed as cancer therapeutics against cancers with higher expression of Ligase IV, as well as against radio- and chemoresistant cancers newline |
Pagination: | 224p. |
URI: | http://hdl.handle.net/10603/426196 |
Appears in Departments: | Biochemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf | Attached File | 30.08 kB | Adobe PDF | View/Open |
02_prelim pages.pdf | 506.48 kB | Adobe PDF | View/Open | |
03_table of contents.pdf | 9.38 kB | Adobe PDF | View/Open | |
04_abstract.pdf | 183.12 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 2.25 MB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 674.07 kB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 2.55 MB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 1.39 MB | Adobe PDF | View/Open | |
09_chapter 5.pdf | 2.42 MB | Adobe PDF | View/Open | |
10_chapter 6.pdf | 834.54 kB | Adobe PDF | View/Open | |
11_annexure.pdf | 1.04 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 187.81 kB | Adobe PDF | View/Open |
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