Formulation and charaterization of clay based film as ocular dexametrasone delivery system

Abstract

he physiological barrier and protective nature of eye hinders the delivery of newlinesignificant amount of drug. Modified formulation could be delivered the medication to newlinethe target site of eye for longer time and provided better therapeutic efficacy, compared newlinewith conventional formulation. Ocular inflammation is effectively treated by potent newlineocular corticosteroid. Dexamethasone is glucocorticosteroid used for inflammation, newlineconjunctivitis, keratitis. Drugs can deliver over long time by introducing any material, newlinewhich can extend the retention and release to target site. The release of drug from matrix newlineis related to the swelling of that matrix. The objective of this study is to evaluate the newlinedexamethasone film containing kaolin for ocular inflammation treatment. The newlinedexamethasone film has been evaluated by swelling, in vitro release and ex vivo newlinepermeation as a kaolin content function and viscosity of hydroxypropyl methylcellulose newlinepolymer. Kaolin has ability to adhere to mucosa and can protect eye by absorbing newlineviruses, toxins, and bacteria.Swelling of hydroxypropyl methylcellulose matrix with newlinevaried kaolin studied as the measurement of hydration of matrix. Peleg and lag phase newlinemodel were utilized to understand the swelling kinetics of matrix. Furthermore, these newlinemodels were modified to evaluate the swelling process. Swelling of matrix was newlinecharacterized by the parameter such as swelling equilibrium,pelegcapacity constant, newlinepeleg rate constant. Permeation of drug through cornea studied byHiguchi and newlineKorsmeyer-Peppas model. Corneal permeation also described by measuring the newlinepermeation coefficient and flux. All film also characterized by FTIR, Differential newlinescanning electrometry, scanning electron microscopy, X-ray diffraction study. Th newline