Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/424227
Title: Entrapment Efficiency and Release Kinetics of Antihypertensive and Anticancer Drugs using Biodegradable Polymer Particles
Researcher: Basu, Tanushree
Guide(s): Singh, Satnam and Pal, Bonamali
Keywords: Anticancer drug
Antihypertensive drug
Chemistry
Chemistry Multidisciplinary
Physical Sciences
polymeric nanoparticles
University: Thapar Institute of Engineering and Technology
Completed Date: 2019
Abstract: The work presented in this thesis enlightens the significance of biodegradable polymeric materials for their intended use as drug delivery carriers. Main emphasis has been given to the synthesis of polymeric nanoparticles (NPs) in the form of coreatshell and hollow nanostructures by varying the nature of core, shell composition, their characterization and application in drug delivery. In order to improve the therapeutic efficacy of ramipril, an antihypertensive drug, a study has been carried out to ascertain the duration of its action. Ramipril loaded biodegradable nanoparticles of poly-D,L-lactide-co-glycolide (PLGA) were prepared by nanoprecipitation using tribloere stabilizer kolliphor P-188 (K P-188). Four different formulations F1 to F4 were prepared by altering the weight of K P-188: PLGA. Further, the core-shell morphology of poly- lactic /poly-lactic-co-glycolic acid- poly N-isopropylacrylamide nanocomposite was assessed to study the release kinetics of ramipril. In-vitro release study of the formulations at pH 5.3 in phosphate buffer indicated poly-lactic-co-glycolic acid to be more efficient than poly- lactic acid with a sustained release of 86% of ramipril from the polymer matrix within 24 hours. Also, chitosan hollow nanospheres were prepared using poly-D,L-lactide-co-glycolide as template by single emulsion method. The in-vitro release of ramipril of 86% and 73% was achieved in acetate (pH-3.3) and phosphate (pH-6.3) buffers respectively while only 48% of ramipril in Tris buffer (pH- 8.0) medium. Korsemeyer-Peppas model of drug release indicated the release of ramipril being swelling controlled. Apart from this surface modification using magnetic nanoparticles to enhance the ability of amphiphilic block polymers by increasing their surface properties was studied. In this study, Fe3O4 modified PLGA-PEG nanocomposite is prepared by double emulsion method. The effectiveness of prepared magnetically modified nanoparticles was determined by encapsulating methotrexate (anticancer drug) into t
Pagination: xviii, 97p.
URI: http://hdl.handle.net/10603/424227
Appears in Departments:School of Chemistry and Biochemistry

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01_title.pdfAttached File19.93 kBAdobe PDFView/Open
02_prelim pages.pdf1.74 MBAdobe PDFView/Open
03_content.pdf437.07 kBAdobe PDFView/Open
04_abstract.pdf338.17 kBAdobe PDFView/Open
05_chapter 1.pdf2.84 MBAdobe PDFView/Open
06_chapter 2.pdf5.97 MBAdobe PDFView/Open
07_chapter 3.pdf4.47 MBAdobe PDFView/Open
08_chapter 4.pdf3.99 MBAdobe PDFView/Open
09_annexures.pdf1.85 MBAdobe PDFView/Open
80_recommendation.pdf351.91 kBAdobe PDFView/Open
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