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http://hdl.handle.net/10603/423410
Title: | Nickel and Palladium Catalyzed Denitrogenative Reaction of 1 2 3 Benzotriazin 4 3h One for Synthesis of Ortho Functionalized Benzamides and Heterocyclic Compounds |
Researcher: | Hari Balakrishnan, M |
Guide(s): | Mannathan,S |
Keywords: | Chemistry Chemistry Medicinal Physical Sciences |
University: | SRM Institute of Science and Technology |
Completed Date: | 2022 |
Abstract: | Organometallic compounds are increasingly being used to mediate or catalyze reactions in the synthesis of pharmaceuticals and fine chemicals. In this context, Palladium- catalyzed cross-coupling reactions are extremely useful for the construction of organic molecules in both academia and industry. Palladium-catalyzed cross-coupling reactions are coupling reactions that take place between an electrophile and a nucleophile (usually an organometallic reagent) and are catalyzed by palladium precursors. Organo halides, such as organo iodides and bromides, have traditionally been used as electrophiles in cross-coupling reactions. Despite the fact that organo iodides and bromides were excellent synthons, their cost and availability limited their utility. Because of this, organo pseudo halides including oxo-sulfonates and aza-sulfonates have been successfully used in transition metal-catalyzed cross-coupling reactions to form various C-C bonds. Even so, these electrophiles can produce an unavoidable amount of waste. Disposal of this waste has been a major issue for industries in bulk scale synthesis. As a result, there is a pressing need to improve environmentally friendly cross-coupling reactions. Triazoles would be regarded as excellent synthons for organic synthesis in this case. In denitrogenative transformation, these will expel eco-friendly molecular nitrogen as a by-product. Triazoles can deliver a variety of nitrogen-containing organic compounds in an efficient and regioselective manner on cross- coupling reactions with various nucleophiles. In this regard, 1,2,3-Benzotriazin-4(3H)-one is a well-known triazole molecule that can be used in a variety of pharmaceuticals and agrochemicals newline |
Pagination: | |
URI: | http://hdl.handle.net/10603/423410 |
Appears in Departments: | Department of Chemistry |
Files in This Item:
File | Description | Size | Format | |
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01_title page.pdf | Attached File | 388.45 kB | Adobe PDF | View/Open |
02_preliminary page.pdf | 805.75 kB | Adobe PDF | View/Open | |
03_content.pdf | 422.33 kB | Adobe PDF | View/Open | |
04_abstract.pdf | 319.76 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 2.01 MB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 791.39 kB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 1.13 MB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 1.18 MB | Adobe PDF | View/Open | |
09_chapter 5.pdf | 1.89 MB | Adobe PDF | View/Open | |
10_chapter 6.pdf | 1.07 MB | Adobe PDF | View/Open | |
11_chapter 7.pdf | 1.29 MB | Adobe PDF | View/Open | |
12_chapter 8.pdf | 618.3 kB | Adobe PDF | View/Open | |
13_annexures.pdf | 11.29 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 700.74 kB | Adobe PDF | View/Open |
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