Synthesis structure and spectroscopic analysis of metal complexes of bioactive pyrimidine derivatives

Abstract

Nature, predominantly operates under the influence of inherent principles of self-assembly, newlinepossesses unparalleled skill at producing highly functional complex molecular machines, out newlineof a very limited number of building blocks - a finite set of 20 amino acids, a few nucleotides, newlinelipids, and available sugars, for instance. The molecular self-assembly occurs through weak newlinenon-covalent forces, which empowers variation, complexity, and differentiation in all life forms newlinein nature. Going through numerous examples such as protein folding, nucleic acid assembly newlineand tertiary structure, formation of phospholipid membranes, ribosomes and microtubules and newlinemany more, nature offers us an inspiration to use the self-assembly concept to synthetically newlinedesign and develop novel architectures with similar complexity and functionality. The choice newlineof specific building blocks and a thorough understanding of non-covalent interactions are the newlinetwo important prerequisites for this purpose. newlineAlthough, amino nitrosouracil and its methyl derivatives (ANU and DANU), 6-chloro- newline3-methyluracil and N, N´-dimethylvioluric acid (DMVA) or {5-(hydroxyimino)-1,3- newlinedimethylpyrimidine-2,4,6(1H,3H,5H)-trione,} are very versatile building blocks, the use of newlinethese molecules for designing of metal ion co-ordination compounds is still limited, as attested newlineby the search conducted in the Cambridge Structural Database (CSD). The main objective of newlinethe present dissertation is to study the metal complexes generated by self-assembly of various newlinemetals and the building block with amino nitrosouracil and its methyl derivatives (ANU and newlineDANU), 6-chloro-3-methyluracil and N,N´-dimethylvioluric acid (DMVA) Or {5- newline(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione,}. newlineThe major concern of this thesis entitled as `Synthesis, structure and spectroscopic newlineanalysis of metal complexes of bioactive pyrimidine derivatives` is to explore the coordination newlinechemistry of copper (II), cobalt (II), nickel (II) towards pyrimidine-based derivatives newlinespecially, uracil derivatives.