Study on caseinolytic proteases clp of pathogenic leptospira interrogans

Abstract

The caseinolytic proteases Clps highly conserved large oligomeric protein complexes found in prokaryotes and eukaryotes These complexes are generally involved in maintaining cellular homeostasis as well as virulence regulation In this study we aimed at characterizing the Clps of pathogenic Leptospira in vitro that might play an essential role in bacterial survival and virulence Bioinformatic analysis of the genome of the sequenced strains of Leptospira interrogans shows the presence of the...