Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/421642
Title: | Molecular Hybridization Approach for the Synthesis And Evaluation Of New Heterocyclic Compounds As Potential Anticancer Agents |
Researcher: | Singh, Iqubal |
Guide(s): | Paul, Kamaldeep |
Keywords: | Chemistry Chemistry Inorganic and Nuclear Chemistry, Organic Heterocyclic chemistry Physical Sciences |
University: | Thapar Institute of Engineering and Technology |
Completed Date: | 2020 |
Abstract: | Hybrids of imidazo[1,2-a] pyrazine-benzimidazole, benzimidazole-naphthalimide, naphthalimide-phenanthro[9,10-d]imidazole, phenanthro[9,10-d]imidazole-various heterocyclic moieties and naphthalimide-benzothiazole-indole were synthesized in moderate to good yield. All synthesized compounds were characterized by 1H, 13C NMR and Mass spectrometry. Synthesized compounds have been evaluated against human cancer cell lines. Interaction with ct-DNA and serum albumin (BSA/HSA) were evaluated using spectroscopy techniques. The binding interactions of compounds with DNA were further confirmed through docking studies. newline |
Pagination: | 217p. |
URI: | http://hdl.handle.net/10603/421642 |
Appears in Departments: | School of Chemistry and Biochemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf | Attached File | 36.27 kB | Adobe PDF | View/Open |
02_prelim pages.pdf | 679.76 kB | Adobe PDF | View/Open | |
03_content.pdf | 473.48 kB | Adobe PDF | View/Open | |
04_abstract.pdf | 406.91 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 1.26 MB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 2.4 MB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 1.87 MB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 1.49 MB | Adobe PDF | View/Open | |
09_chapter 5.pdf | 1.31 MB | Adobe PDF | View/Open | |
10_chapter 6.pdf | 804.86 kB | Adobe PDF | View/Open | |
11_annexures.pdf | 1.51 MB | Adobe PDF | View/Open | |
80_recommendation.pdf | 840.55 kB | Adobe PDF | View/Open |
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