Interfacial activity and membrane binding properties of 945 synuclein and its parkinson s disease variants

Abstract

Parkinson 8482 s disease is a movement disorder that happens due to the loss of neurons in the brain 8482 s nigral dopaminergic pathway The accumulation of the protein 206 177 synuclein 206 177 S in the nigrostriatal pathway has been held responsible for the loss of neurons in the substantia nigra pars compacta SNpc The disease 8482 s familial form is associated with gene duplication and six missense mutations in the 206 177 S gene that translate to the mutant proteins In the disease 8482 s sporadic form various env...