Development of aptamer probes against two wheat 945 gliadin peptides containing dq2 5 restricted celiac epitopes glia 945 1a glia 945 1b glia 945 2 and glia 945 3

Abstract

The presence of toxic and immunogenic epitopes in wheat causes celiac disease when consumed by susceptible individuals with genetic predisposition The detection is of prime importance for the management of this chronic inflammatory disease which is also caused by the consumption of other cereals like barley and rye The present study focused on the development of aptamer probes against two peptide sequences present in the alpha gliadin subunit of wheat gluten protein which contain few epitopes...