Tailoring short self assembling peptides into biocompatible gelators

Abstract

The thesis largely focuses on the self assembly of designed amyloidogenic and fatty acylated peptides and their potential applications in healthcare The short amyloidogenic stretch of 206 178 amyloid A 206 178 16 22 Ac KLVFFAE am is a useful model peptide to study the aspects of 206 178 amyloid fibril formation Herein the self assembly was investigated by incorporating 206 178 turn inducing motifs Asn Gly DPro Gly and Aib DPro in the Ac KLVXZAE am chains where X and Z are the aromatic amino acids Phe T...