Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/419380
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dc.date.accessioned2022-11-16T09:07:07Z-
dc.date.available2022-11-16T09:07:07Z-
dc.identifier.urihttp://hdl.handle.net/10603/419380-
dc.description.abstractIn-silico approach was used to select thirty molecules which are predicted to be effective against the target enzyme HMG -Co-A and the protein was downloaded from Protein Bank (PDB id-1t02). This was done by molecular docking studies against the target enzyme and the ligands. In-silico ADME assessment and In-silico toxicity predictions were carried out to find the drug likeness property and toxicity nature of the selected 30 molecules after docking. 30 molecules which were selected from docking score were synthesized. The synthesised molecules are 1,2,3 triazole derivatives of Coumarin, Quinoline and Pthalimide. Thirty new molecules comprises of newlineo 14 number of 1,2,3 triazole derivatives of Coumarin (5a-5g and 6a-6g). newlineo 14 number of 1,2,3 triazole derivatives of Quinoline (9a-9g and 10a-10g). newlineo 2 number of 1,2,3 triazole derivatives of Pthalimide (13a-13b). newlineThe thirty synthesised compounds were purified by chromatography using ethyl acetate and hexane (1:2) as eluting agent. Melting point was determined by open capillary method and are presented uncorrected. All the molecules were characterized by FT-IR,1H-NMR,13C-NMR and Mass spectra. In the present work, simple and efficient practical methods were adopted for the synthesis of the heterocyclics which resulted from the in-silico and the compounds were obtained in good yield. newlineAnti-hyperlipidemic activity was carried out by feeding high fat diet to 7 groups of six animals each and at the end of nine weeks, animals were sacrificed. All the synthesized compounds showed increase in HDL level of the animals as compared to the group which was administered with standard drug. The compound reduced the body weight of the animals which are fed with high fat diet at a lower dose and also decreased the level of LDL in the blood. The good profile of the molecules with the In-silico toxicity and In-silico ADME properties shows it can be taken for further studies. The above findings have demonstrated that the compound is possibly a future drug moiety for treating hyperlipidemia.
dc.format.extent142
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleDesign Synthesis and Pharmacological Evaluation of Some Novel Heterocyclic Antihyperlipidemic Agents
dc.title.alternative
dc.creator.researcherSaraswathy T
dc.subject.keywordDesign
dc.subject.keywordNovel Heterocyclic Antihyperlipidemic Agents
dc.subject.keywordPharmacological Evaluation
dc.subject.keywordSynthesis
dc.description.note
dc.contributor.guideNiraimathi V
dc.publisher.placeChennai
dc.publisher.universityThe Tamil Nadu Dr. M.G.R. Medical University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered
dc.date.completed2016
dc.date.awarded2021
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File460.88 kBAdobe PDFView/Open
02_prelim pages.pdf1.43 MBAdobe PDFView/Open
03_content.pdf18.44 kBAdobe PDFView/Open
05_chapter 1.pdf1.15 MBAdobe PDFView/Open
06_chapter 2.pdf374.67 kBAdobe PDFView/Open
07_chapter 3.pdf209.16 kBAdobe PDFView/Open
08_chapter 4.pdf300.82 kBAdobe PDFView/Open
09_chapter 5.pdf4.22 MBAdobe PDFView/Open
10_annexures.pdf582.87 kBAdobe PDFView/Open
10_chapter 6.pdf968.74 kBAdobe PDFView/Open
11_chapter 7.pdf620.93 kBAdobe PDFView/Open
80_recommendation.pdf855.57 kBAdobe PDFView/Open


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