Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/419370
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dc.date.accessioned2022-11-16T09:05:27Z-
dc.date.available2022-11-16T09:05:27Z-
dc.identifier.urihttp://hdl.handle.net/10603/419370-
dc.description.abstractnewline Colon cancer (CC) is a devastating cancer that originates in the large intestine. Its incidence and mortality rate are increasing worldwide with the improvement of living standards and lifestyle changes in recent years especially in developing countries. Due to lack of effective medicines and diagnostic tools, controlling CC has become difficult. Chemotherapy, radiotherapy, immunotherapy and surgery are the most common available treatments, but patients were afflicted with severe side effects including alopecia, bleeding immunosuppression and diarrhea which results in more complication. To avoid the undesired effects of chemotherapy and surgical complications, alternative strategies are being explored like phyto therapeutics. Successful integration of in vitro and in vivo experimental data sets can afford projections of human dose regimens anticipated to be safe and therapeutically beneficial. While in vitro experiments guide new chemical synthesis and are essential to understand the mechanism of drug action and disposition, in vivo characterizations provide unique insight into complex biological systems that control concentrations at the site of action and pharmacologic response. In this regard present study is aimed at determining the anticancer efficacy of Sida acuta Burm.f leaves and its phyto-constituents using azoxymethane induction rat model and colon HCT-116 cells. A goal of this preclinical discovery is the identification of drug candidates suitable for clinical testing.
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dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleAnticancer activity of Sida acuta Burm f leaves against colon cancer by in vivo and in vitro approaches
dc.title.alternative
dc.creator.researcherP Muneeswari
dc.subject.keywordBiochemistry and Molecular Biology
dc.subject.keywordBiology and Biochemistry
dc.subject.keywordLife Sciences
dc.description.note
dc.contributor.guideK Poornima
dc.publisher.placeCoimbatore
dc.publisher.universityKarpagam University
dc.publisher.institutionBiochemistry
dc.date.registered2016
dc.date.completed2020
dc.date.awarded2020
dc.format.dimensions
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Biochemistry

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80_recommendation.pdfAttached File215.02 kBAdobe PDFView/Open
abstract.pdf181.16 kBAdobe PDFView/Open
certificate.pdf205.96 kBAdobe PDFView/Open
chapter 1.pdf699.86 kBAdobe PDFView/Open
chapter 2.pdf1.57 MBAdobe PDFView/Open
chapter 3.pdf529.17 kBAdobe PDFView/Open
contents.pdf252.92 kBAdobe PDFView/Open
declaration.pdf205.78 kBAdobe PDFView/Open
introduction.pdf488.48 kBAdobe PDFView/Open
references.pdf399.34 kBAdobe PDFView/Open
title page.pdf161.02 kBAdobe PDFView/Open


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